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Master-/Doktorarbeit an der TUM

Project Title: Structure-function relationship of Cas-endonucleases

Project description:
CRISPR-Cas systems are used by prokaryotes to defend themselves against phages, invading nucleic acids and mobile genetic elements. These adaptive immune systems consist of a genomic CRISPR-locus, which is transcribed in the crRNA and one (or a complex) effector nuclease, that cleaves the target nucleic acid in a crRNA-sequence dependent manner. The RNA-guided, sequence-dependent cleavage of double stranded DNA by the Cas9 endonuclease of Streptococcus pyogenes is currently exploited for the site-specific genome modification of various organisms and has revolutionized the field of biology.
Prokaryotes and archaea possess numerous, highly diverse Cas-systems, with to date unknown natural functions and mechanisms of action, as well as a large number of such systems still remaining to be discovered. Recent studies show that CRISPR-Cas systems are not merely prokaryotic defence mechanisms, but also play a role in DNA repair, regulation of gene expression, virulence and horizontal gene transfer.

We are part of the Priority Program "More than defence: the multiple functions and facets of CRISPR-Cas", and are interested in the function and structural biology of novel Cas-endonucleases and are looking for a highly motivated Master and/or PhD student of chemistry, biochemistry or related subject to join our team.

Funding available starting from: 01.03.2019, contact sabine.schneider@mytum.de

 

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