Master thesis available in the Schiller lab @HelmholtzMunich
Multiplexed and volumetric imaging of human organs to characterize capillary cell plasticity in lung injury and fibrogenesis
23.05.2024
Master thesis available in the Schiller lab @HelmholtzMunich
Multiplexed and volumetric imaging of human organs to characterize capillary cell plasticity in lung injury and fibrogenesis
Supervisors
Dr. Lin Yang (lin.yang@helmholtz-munich.de), & Prof. Dr. Herbert Schiller, Director of Research Unit for Precision Regenerative Medicine, Helmholtz Munich
Project Background
Fibrogenesis after tissue injury is one of the most prevalent clinical complications and causes
of death. One of the archetypal examples of an organ fibrosis is the lethal disease Idiopathic
Pulmonary Fibrosis (IPF), a relentless fibrotic lung disease characterized by the progressive
scarring of alveolar tissues with dramatic changes in epithelial, endothelial and fibroblast cell
states during disease progression (1-2). The main aim of our research is to understand how
these aberrant cell states are wired together into circuits and thereby influencing each other
throughout disease evolution (3-6). To better understand the altered cell-cell communication
inducing these disease-specific circuits, we use state-of-the art single cell-omics technologies,
innovative imaging tools and organotypic ex vivo models.
...
All information can be found in the PDF.
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