Research internship and/or Master Thesis in Immunological Diabetes Research
30.09.2024 um 00:00 Uhr
Research internship and/or Master Thesis in Immunological Diabetes Research offered at the
Research Unit for Type 1 Diabetes Immunology Helmholtz Diabetes Center Helmholtz Center Munich.
Topic: Impact of CCR4 ligands on tissue Treg cells in islet autoimmunity.
Chemokine ligand (CCL) 22 and CCL17 are important mediators of T-cell trafficking with supposed
anti- and pro-inflammatory properties respectively and transduce signal to Tregs via the Chemokine
receptor (CCR) 4, highly expressed on Tregs. CCL22-CCR4 interaction leads to Treg migration and
dendritic cell (DC)-Treg crosstalk resulting in immune suppression, however the latter has not yet
been fully demonstrated.
The current project aims to investigate the involvement of CCL22/17-CCR4 axis in the context of
islet autoimmunity preceding overt T1D and study its effect on Treg induction, stability, and
function with particular attention to pathological implications.
Further information can be found here.